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Effect of beta-blocker therapy in patients with or without left ventricular systolic dysfunction after acute myocardial infarction

Authors
Joo, Seung-JaeKim, Song-YiChoi, Joon-HyoukPark, Hyeung KeunBeom, Jong WookLee, Jae-GeunChae, Shung ChullKim, Hyo-SooKim, Young JoCho, Myeong ChanKim, Chong JinRha, Seung-WoonYoon, JunghanJeong, Myung Ho
Issue Date
Nov-2021
Publisher
OXFORD UNIV PRESS
Keywords
Beta-blockers; Myocardial infarction; Ventricular ejection fraction; Outcome
Citation
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v.7, no.6, pp.475 - 482
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
Volume
7
Number
6
Start Page
475
End Page
482
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135981
DOI
10.1093/ehjcvp/pvaa029
ISSN
2055-6837
Abstract
Aims This observational study aimed to investigate the association between beta-blocker therapy and clinical outcomes in patients with acute myocardial infarction (AMI), especially with mid-range or preserved left ventricular systolic function. Methods and results Among 13 624 patients enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH), 12 200 in-hospital survivors were selected. Patients with beta-blockers showed significantly lower 1-year major adverse cardiac events (MACE), which was a composite of cardiac death, MI, revascularization, and readmission due to heart failure [9.7 vs. 14.3/100 patient-year; hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.72-0.97; P=0.022). However, this association had a significant interaction with left ventricular ejection fraction (LVEF). Beta-blocker therapy at discharge was associated with lower 1-year MACE in patients with LVEF <= 40% (HR 0.63, 95% CI 0.48-0.81; P<0.001), and 40% <LVEF<50% (HR 0.69, 95% CI 0.51-0.94; P=0.020), but not in patients with LVEF >= 50% (HR 1.16, 95% CI 0.91-1.48; P=0.234). Conclusions Beta-blocker therapy at discharge was associated with better 1-year clinical outcomes in patients with reduced or mid-range LVEF after AMI, but not in patients with preserved LVEF. These data suggested that the long-term beta-blocker therapy may be guided by LVEF.
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