Effect of beta-blocker therapy in patients with or without left ventricular systolic dysfunction after acute myocardial infarction
- Authors
- Joo, Seung-Jae; Kim, Song-Yi; Choi, Joon-Hyouk; Park, Hyeung Keun; Beom, Jong Wook; Lee, Jae-Geun; Chae, Shung Chull; Kim, Hyo-Soo; Kim, Young Jo; Cho, Myeong Chan; Kim, Chong Jin; Rha, Seung-Woon; Yoon, Junghan; Jeong, Myung Ho
- Issue Date
- 11월-2021
- Publisher
- OXFORD UNIV PRESS
- Keywords
- Beta-blockers; Myocardial infarction; Ventricular ejection fraction; Outcome
- Citation
- EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v.7, no.6, pp.475 - 482
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
- Volume
- 7
- Number
- 6
- Start Page
- 475
- End Page
- 482
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135981
- DOI
- 10.1093/ehjcvp/pvaa029
- ISSN
- 2055-6837
- Abstract
- Aims This observational study aimed to investigate the association between beta-blocker therapy and clinical outcomes in patients with acute myocardial infarction (AMI), especially with mid-range or preserved left ventricular systolic function. Methods and results Among 13 624 patients enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH), 12 200 in-hospital survivors were selected. Patients with beta-blockers showed significantly lower 1-year major adverse cardiac events (MACE), which was a composite of cardiac death, MI, revascularization, and readmission due to heart failure [9.7 vs. 14.3/100 patient-year; hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.72-0.97; P=0.022). However, this association had a significant interaction with left ventricular ejection fraction (LVEF). Beta-blocker therapy at discharge was associated with lower 1-year MACE in patients with LVEF <= 40% (HR 0.63, 95% CI 0.48-0.81; P<0.001), and 40% <LVEF<50% (HR 0.69, 95% CI 0.51-0.94; P=0.020), but not in patients with LVEF >= 50% (HR 1.16, 95% CI 0.91-1.48; P=0.234). Conclusions Beta-blocker therapy at discharge was associated with better 1-year clinical outcomes in patients with reduced or mid-range LVEF after AMI, but not in patients with preserved LVEF. These data suggested that the long-term beta-blocker therapy may be guided by LVEF.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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