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Evaluation of antitumor metastasis via immunostimulating activities of pectic polysaccharides isolated from radish leaves

Authors
Son, Seung-UPark, Ho YoungSuh, Hyung JooShin, Kwang-Soon
Issue Date
10월-2021
Publisher
ELSEVIER
Keywords
Anti-metastasis; Macrophage activation; NK cell cytotoxicity; Radish leaf polysaccharide
Citation
JOURNAL OF FUNCTIONAL FOODS, v.85
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
85
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136237
DOI
10.1016/j.jff.2021.104639
ISSN
1756-4646
Abstract
We investigated the antimetastatic effects of polysaccharides (RWP) isolated from radish leaves by hot water extraction and ethanol precipitation. From the sugar composition analysis, RWP was estimated to be a pectic polysaccharide. Peritoneal macrophages stimulated with RWP significantly augmented the production of various cytokines. In an assay for natural killer (NK) cell activity, both intravenous (i.v.) and oral administration of RWP significantly enhanced NK cells cytotoxicity against YAC-1 lymphoma. In an experiment on lung metastasis of Colon26-M3.1 carcinoma, prophylactic i.v. and oral administration of RWP inhibited metastasis by 77.2% and 55.0%, respectively, at 1000 mu g/mouse. Furthermore, pretreatment with anti-asialo GM1 for NK cells depletion partly suppressed the inhibitory effect of RWP on lung metastasis. Thus, our study results suggest that RWP has superior antimetastatic activity, and this effect is related to the activation of various immune factors.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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