Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Seong Ho | - |
dc.contributor.author | Kim, Hye Ryun | - |
dc.contributor.author | Kim, Jeonghun | - |
dc.contributor.author | Kim, Hankyeol | - |
dc.contributor.author | Hong, Namki | - |
dc.contributor.author | Jung, Jin Ho | - |
dc.contributor.author | Baik, Kyoungwon | - |
dc.contributor.author | Cho, Hanna | - |
dc.contributor.author | Lyoo, Chul Hyoung | - |
dc.contributor.author | Ye, Byoung Seok | - |
dc.contributor.author | Sohn, Young H. | - |
dc.contributor.author | Seong, Joon-Kyung | - |
dc.contributor.author | Lee, Phil Hyu | - |
dc.date.accessioned | 2022-02-21T07:42:07Z | - |
dc.date.available | 2022-02-21T07:42:07Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-09-14 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136356 | - |
dc.description.abstract | Background and Objective To investigate whether dipeptidyl peptidase-4 inhibitors (DPP-4i) have beneficial effects on amyloid aggregation and longitudinal cognitive outcome in diabetic Alzheimer disease-related cognitive impairment (ADCI). Methods We retrospectively reviewed 282 patients with ADCI with positive F-18-florbetaben amyloid PET images. Patients were classified into 3 groups according to prior diagnosis of diabetes and DPP-4i use: diabetic patients being treated with (ADCI-DPP-4i(+), n = 70) or without DPP-4i (ADCI-DPP-4i(-), n = 71) and nondiabetic patients (n = 141). Multiple linear regression analyses were performed to determine intergroup differences in global and regional amyloid retention using standardized uptake value ratios calculated from cortical areas. We assessed longitudinal changes in Mini-Mental State Examination (MMSE) score using a linear mixed model. Results The ADCI-DPP-4i(+) group had lower global amyloid burden than the ADCI-DPP-4i(-) group (beta = 0.075, SE = 0.024, p = 0.002) and the nondiabetic ADCI group (beta = 0.054, SE = 0.021, p = 0.010) after adjusting for age, sex, education, cognitive status, and APOE epsilon 4 carrier status. The ADCI-DPP-4i(+) group had lower regional amyloid burden in temporo-parietal areas than either the ADCI-DPP-4i(-) group or the nondiabetic ADCI group. The ADCI-DPP-4i(+) group showed a slower longitudinal decrease in MMSE score (beta = 0.772, SE = 0.272, p = 0.005) and memory recall subscore (beta = 0.291, SE = 0.116, p = 0.012) than the ADCI-DPP-4i(-) group. Discussion These findings suggest that DPP-4i use is associated with low amyloid burden and favorable long-term cognitive outcome in diabetic patients with ADCI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | DPP-4 INHIBITOR | - |
dc.subject | DIAGNOSTIC GUIDELINES | - |
dc.subject | NATIONAL INSTITUTE | - |
dc.subject | BETA PLAQUES | - |
dc.subject | DEMENTIA | - |
dc.subject | DECLINE | - |
dc.subject | PET | - |
dc.subject | RECOMMENDATIONS | - |
dc.subject | SITAGLIPTIN | - |
dc.title | Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Joon-Kyung | - |
dc.identifier.doi | 10.1212/WNL.0000000000012534 | - |
dc.identifier.scopusid | 2-s2.0-85116956911 | - |
dc.identifier.wosid | 000702412700025 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.97, no.11, pp.E1110 - E1122 | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 97 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | E1110 | - |
dc.citation.endPage | E1122 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BETA PLAQUES | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | DIAGNOSTIC GUIDELINES | - |
dc.subject.keywordPlus | DPP-4 INHIBITOR | - |
dc.subject.keywordPlus | NATIONAL INSTITUTE | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | SITAGLIPTIN | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.