Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment

Authors
Jeong, Seong HoKim, Hye RyunKim, JeonghunKim, HankyeolHong, NamkiJung, Jin HoBaik, KyoungwonCho, HannaLyoo, Chul HyoungYe, Byoung SeokSohn, Young H.Seong, Joon-KyungLee, Phil Hyu
Issue Date
14-9월-2021
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
NEUROLOGY, v.97, no.11, pp.E1110 - E1122
Indexed
SCIE
SCOPUS
Journal Title
NEUROLOGY
Volume
97
Number
11
Start Page
E1110
End Page
E1122
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136356
DOI
10.1212/WNL.0000000000012534
ISSN
0028-3878
Abstract
Background and Objective To investigate whether dipeptidyl peptidase-4 inhibitors (DPP-4i) have beneficial effects on amyloid aggregation and longitudinal cognitive outcome in diabetic Alzheimer disease-related cognitive impairment (ADCI). Methods We retrospectively reviewed 282 patients with ADCI with positive F-18-florbetaben amyloid PET images. Patients were classified into 3 groups according to prior diagnosis of diabetes and DPP-4i use: diabetic patients being treated with (ADCI-DPP-4i(+), n = 70) or without DPP-4i (ADCI-DPP-4i(-), n = 71) and nondiabetic patients (n = 141). Multiple linear regression analyses were performed to determine intergroup differences in global and regional amyloid retention using standardized uptake value ratios calculated from cortical areas. We assessed longitudinal changes in Mini-Mental State Examination (MMSE) score using a linear mixed model. Results The ADCI-DPP-4i(+) group had lower global amyloid burden than the ADCI-DPP-4i(-) group (beta = 0.075, SE = 0.024, p = 0.002) and the nondiabetic ADCI group (beta = 0.054, SE = 0.021, p = 0.010) after adjusting for age, sex, education, cognitive status, and APOE epsilon 4 carrier status. The ADCI-DPP-4i(+) group had lower regional amyloid burden in temporo-parietal areas than either the ADCI-DPP-4i(-) group or the nondiabetic ADCI group. The ADCI-DPP-4i(+) group showed a slower longitudinal decrease in MMSE score (beta = 0.772, SE = 0.272, p = 0.005) and memory recall subscore (beta = 0.291, SE = 0.116, p = 0.012) than the ADCI-DPP-4i(-) group. Discussion These findings suggest that DPP-4i use is associated with low amyloid burden and favorable long-term cognitive outcome in diabetic patients with ADCI.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Artificial Intelligence > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE