Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age
DC Field | Value | Language |
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dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Kim, Suhyeon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Jo, Kyungae | - |
dc.date.accessioned | 2022-02-22T00:41:52Z | - |
dc.date.available | 2022-02-22T00:41:52Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136440 | - |
dc.description.abstract | Amino acids, as nutrients, are expected to improve sleep disorders. This study aimed to evaluate the generation- and age-dependent sleep-improving effects of gamma-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) coadministration. The differentially expressed genes and generation-related behavior after the administration of a GABA/5-HTP mixture were measured in a Drosophila model, while age-related changes in gene expression and oxidative stress-related parameters were measured in a mouse model. The GABA/5-HTP-treated group showed significant behavioral changes compared to the other groups. Sequencing revealed that the GABA/5-HTP mixture influenced changes in nervous system-related genes, including those involved in the regulation of the expression of behavioral and synaptic genes. Additionally, total sleep time increased with age, and nighttime sleep time in the first- and third-generation flies was significantly different from that of the control groups. The GABA/5-HTP mixture induced significant changes in the expression of sleep-related receptors in both models. Furthermore, the GABA/5-HTP mixture reduced levels of ROS and ROS reaction products in an age-dependent manner. Therefore, the increase in behavioral changes caused by GABA/5-HTP mixture administration was effective in eliminating ROS activity across generations and ages. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | SLOW-WAVE ACTIVITY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | GABA/5-HTP MIXTURE | - |
dc.subject | PROMOTE SLEEP | - |
dc.subject | SEROTONIN | - |
dc.subject | 5-HYDROXYTRYPTOPHAN | - |
dc.subject | RECEPTORS | - |
dc.subject | NEURONS | - |
dc.subject | QUANTIFICATION | - |
dc.subject | METABOLITES | - |
dc.title | Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.3390/ijms22189822 | - |
dc.identifier.scopusid | 2-s2.0-85114631042 | - |
dc.identifier.wosid | 000699832000001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.18 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | 5-HYDROXYTRYPTOPHAN | - |
dc.subject.keywordPlus | GABA/5-HTP MIXTURE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | PROMOTE SLEEP | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | SLOW-WAVE ACTIVITY | - |
dc.subject.keywordAuthor | 5-hydroxytryptophan | - |
dc.subject.keywordAuthor | age | - |
dc.subject.keywordAuthor | gamma-aminobutyric acid | - |
dc.subject.keywordAuthor | generation | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | sleep | - |
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