Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
- Authors
- Jang, Hochung; Kim, Eun Hye; Chi, Sung-Gil; Kim, Sun Hwa; Yang, Yoosoo
- Issue Date
- 9월-2021
- Publisher
- MDPI
- Keywords
- cancer therapy; innate immune cells; nanoparticles; tumor microenvironment
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.18
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 22
- Number
- 18
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136454
- DOI
- 10.3390/ijms221810009
- ISSN
- 1661-6596
- Abstract
- A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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