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Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Authors
Kim, EunmiLee, Dong-WonPark, Hae-ChulKim, Dong Hwee
Issue Date
9월-2021
Publisher
ELSEVIER
Keywords
Alpha-lipoic acid; Diabetes mellitus; Hair cell; Pancreatic beta-cell; Zebrafish
Citation
MOLECULAR GENETICS AND METABOLISM REPORTS, v.28
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR GENETICS AND METABOLISM REPORTS
Volume
28
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136473
DOI
10.1016/j.ymgmr.2021.100783
ISSN
2214-4269
Abstract
Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.
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