Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Park, Dongmin | - |
dc.contributor.author | Lee, Sora | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Kim, Kyung Eun | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Park, Hyun Jeong | - |
dc.contributor.author | Cho, Daeho | - |
dc.date.accessioned | 2022-02-22T22:42:25Z | - |
dc.date.available | 2022-02-22T22:42:25Z | - |
dc.date.created | 2022-02-15 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136553 | - |
dc.description.abstract | Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | T-CELL-ACTIVATION | - |
dc.subject | NFAT | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | PLAYS | - |
dc.subject | GENE | - |
dc.title | Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.3390/ijms23020844 | - |
dc.identifier.scopusid | 2-s2.0-85122778300 | - |
dc.identifier.wosid | 000747863000001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.2 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | T-CELL-ACTIVATION | - |
dc.subject.keywordPlus | NFAT | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PLAYS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Erdr1 | - |
dc.subject.keywordAuthor | TCR signal modulation | - |
dc.subject.keywordAuthor | PLC gamma 1 | - |
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