Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway
- Authors
- Kim, Myun Soo; Park, Dongmin; Lee, Sora; Park, Sunyoung; Kim, Kyung Eun; Kim, Tae Sung; Park, Hyun Jeong; Cho, Daeho
- Issue Date
- 1월-2022
- Publisher
- MDPI
- Keywords
- Erdr1; TCR signal modulation; PLC gamma 1
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.2
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 23
- Number
- 2
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136553
- DOI
- 10.3390/ijms23020844
- ISSN
- 1661-6596
- Abstract
- Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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