Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Recreational Physical Activity, Sitting, and Androgen Metabolism among Postmenopausal Women in the Women's Health Initiative Observational Study

Authors
Oh, HannahSaquib, NazmusOchs-Balcom, Heather M.Pfeiffer, Ruth M.Richey, Phyllis A.Shadyab, Aladdin H.Wild, Robert A.Underland, LisaAnderson, Garnet L.Xu, XiaTrabert, Britton
Issue Date
1월-2022
Publisher
AMER ASSOC CANCER RESEARCH
Citation
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v.31, no.1, pp.97 - 107
Indexed
SCIE
SCOPUS
Journal Title
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume
31
Number
1
Start Page
97
End Page
107
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136584
DOI
10.1158/1055-9965.EPI-21-0809
ISSN
1055-9965
Abstract
Background: Prolonged sitting and physical inactivity are associated with higher circulating levels of estrogens. It is unknown whether these risk factors are associated with circulating androgens/androgen metabolites, another set of hormones implicated in the etiology of cancers in postmenopausal women. Methods: We conducted a cross-sectional analysis of 1,782 postmenopausal women in the Women's Health Initiative Observational Study. Serum concentrations of 12 androgens/androgen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Physical activity and sitting time were self-reported at baseline. We performed linear regression to estimate geometric means (GM) of androgen/androgen metabolite concentrations (pmol/L) according to physical activity and sitting time, adjusting for potential confounders and stratified by menopausal hormone therapy (MHT) use. Results: Physical activity (>= 15 vs. 0 MET-h/wk) was inversely associated with estrogen-to-androgen ratios among never/former MHT users (adj-GM - 37.5 vs. 49.6 unconjugated estrone:androstenedione; 20.2 vs. 30.3 unconjugated estradiol:testosterone; all P-trend <= 0.03) but was not associated among current MHT users. Prolonged sitting (>= 10 vs. <= 5h/d) was positively associated with these ratios among both never/former (adj-GM = 44.2 vs. 38.3, P-trend = 0.10; adj-GM = 23.4 vs. 20.2, P-trend = 0.17; respectively) and current MHT users (adj-GM = 197 vs. 147; 105 vs. 75.5; respectively; all P-trend <= 0.02), but the associations were statistically significant among current MHT users only. The associations persisted after adjustment for BMI. After adjustment for adrenal androgens, physical activity and sitting were not associated with androgen metabolites. Conclusions: Physical activity and sitting were associated with serum estrogen-to-androgen ratios but not androgen metabolites. Impact: This study contributes to our understanding of the link between physical activity, sitting, and cancer risk in postmenopausal women.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Public Health Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE