Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Dianthiamides A-E, Proline-Containing Orbitides from Dianthus chinensis
- Authors
- Lee, Jin Woo; Kim, Jun Gu; Han, Jae Sang; Cho, Yong Beom; Lee, Yu Jin; Lee, Dongho; Shin, Dae Hwan; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- Dianthus chinensis; Caryophyllaceae; orbitide; structure elucidation; cytotoxic activity
- Citation
- MOLECULES, v.26, no.23
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULES
- Volume
- 26
- Number
- 23
- ISSN
- 1420-3049
- Abstract
- Orbitides are plant-derived small cyclic peptides with a wide range of biological activities. Phytochemical investigation of the whole plants of Dianthus chinensis was performed with the aim to discover new bioactive orbitides. Five undescribed proline-containing orbitides, dianthiamides A-E (1-5), were isolated from a methanolic extract of Dianthus chinensis. Their structures were elucidated by extensive analysis of 1D and 2D NMR and HRESI-TOF-MS as well as ESI-MS/MS fragmentation data. The absolute configuration of the amino acid residues of compounds 1-5 was determined by Marfey's method. All compounds were tested for their cytotoxic activity, and dianthiamide A (1) exhibited weak activity against A549 cell line with IC50 value of 47.9 mu M.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology