Risk factors for neutropenic fever in non-Hodgkin's lymphoma patients with primary granulocyte colony-stimulating factor prophylaxis
- Authors
- Kim, Yu Ri; Kim, Soo-Jeong; Park, Yong; Oh, Sung Yong; Yun, Hwan-Jung; Mun, Yeung-Chul; Kim, Jin Seok
- Issue Date
- 9월-2021
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Albumin; Elderly; Febrile neutropenia; Female; Lymphoma; non-Hodgkin
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.36, no.5, pp.1181 - 1189
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 36
- Number
- 5
- Start Page
- 1181
- End Page
- 1189
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136700
- DOI
- 10.3904/kjim.2020.206
- ISSN
- 1226-3303
- Abstract
- Background/Aims: Febrile neutropenia (FN) interferes with the proper chemo-therapy dose density or intensity in non-Hodgkin's lymphoma (NHL) patients. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) +/- rituximab has an intermediate FN risk. Prophylactic granulocyte col-ony-stimulating factor (G-CSF) support is recommended for patients with other host-related risk factors. Methods: We evaluated the risk factors for FN-related admission in NHL patients who have received primary G-CSF (lenograstim) prophylaxis. Results: Data from 148 patients were analyzed. The incidence of neutropenic fe -ver was 96 events (12.2%), and the median period was 3.85 days (range, 0 to 5.9); the median duration of neutropenia was 4.21 days (range, 3.3 to 5.07). Eighty-three FN-related admissions were reported. Advanced age (> 60 years), female sex, a low albumin level, and prednisone use were associated with FN-related admission in multivariable analysis (p = 0.010, p < 0.001, and p = 0.010, respectively). A compar-ison between diffuse large B-cell lymphoma patients treated with R-CHOP and pegylated G-CSF and those treated with R-CHOP and lenograstim did not reveal significant differences in the FN-related admission rate between the two groups, although the lenograstim-treated group had a higher incidence of severe neutro-penia. Conclusions: Elderly patients, female patients, and patients with low albumin levels need to be actively followed-up for FN even when primary prophylaxis with G-CSF has been used.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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