Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, Yoonmi | - |
dc.contributor.author | Kang, Wooyoung | - |
dc.contributor.author | Kang, Youbin | - |
dc.contributor.author | Kim, Aram | - |
dc.contributor.author | Han, Kyu-Man | - |
dc.contributor.author | Tae, Woo-Suk | - |
dc.contributor.author | Ham, Byung-Joo | - |
dc.date.accessioned | 2022-02-24T10:41:10Z | - |
dc.date.available | 2022-02-24T10:41:10Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136732 | - |
dc.description.abstract | Objective Although bipolar II disorder (BD II) is not simply a mitigated form of bipolar I disorder (BD I), their neurobiological differ-ences have not been elucidated. The present study aimed to explore cortical thickness (CT) and surface area (SA) in patients with BD I and BD II and healthy controls (HCs) to investigate the shared and unique neurobiological mechanisms of BD subtypes. Methods We enrolled 30 and 44 patients with BD I and BD II, respectively, and 100 HCs. We evaluated CT and SA using FreeSurfer and estimated differences in CT and SA among the three groups (BD I vs. BD II vs. HC). We adjusted for age, sex, educational level, and intracranial volume as confounding factors. Results We found widespread cortical thinning in the bilateral frontal, temporal, and occipital regions; cingulate gyrus; and insula in patients with BD. Alterations in SA, including increased SA of the pars triangularis and decreased SA of the insula, were noted in pa-tients with BD. Overall, we found BD II patients demonstrated decreased SA in the right long insula compared to BD I patients. Conclusion Our results suggest that decreased SA in the right long insula is crucial for differentiating BD subtypes. Psychiatry Investigation 2021;18(9):850-863 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.subject | WHITE-MATTER INTEGRITY | - |
dc.subject | ANTERIOR CINGULATE | - |
dc.subject | GEOMETRICALLY ACCURATE | - |
dc.subject | RATING-SCALE | - |
dc.subject | CORTEX | - |
dc.subject | VOLUME | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | SEGMENTATION | - |
dc.subject | NEUROBIOLOGY | - |
dc.subject | PERFORMANCE | - |
dc.title | Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Kyu-Man | - |
dc.contributor.affiliatedAuthor | Tae, Woo-Suk | - |
dc.contributor.affiliatedAuthor | Ham, Byung-Joo | - |
dc.identifier.doi | 10.30773/pi.2021.0074 | - |
dc.identifier.scopusid | 2-s2.0-85119144538 | - |
dc.identifier.wosid | 000717092900007 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.18, no.9, pp.850 - + | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 18 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 850 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002756024 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | ANTERIOR CINGULATE | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | GEOMETRICALLY ACCURATE | - |
dc.subject.keywordPlus | NEUROBIOLOGY | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | SEGMENTATION | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | WHITE-MATTER INTEGRITY | - |
dc.subject.keywordAuthor | Bipolar disorder | - |
dc.subject.keywordAuthor | Bipolar subtype | - |
dc.subject.keywordAuthor | Cortical thickness | - |
dc.subject.keywordAuthor | Long insula | - |
dc.subject.keywordAuthor | Surface area | - |
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