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Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Authors
Woo, YoonmiKang, WooyoungKang, YoubinKim, AramHan, Kyu-ManTae, Woo-SukHam, Byung-Joo
Issue Date
9월-2021
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Bipolar disorder; Bipolar subtype; Cortical thickness; Long insula; Surface area
Citation
PSYCHIATRY INVESTIGATION, v.18, no.9, pp.850 - +
Indexed
SCIE
SSCI
SCOPUS
KCI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
18
Number
9
Start Page
850
End Page
+
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136732
DOI
10.30773/pi.2021.0074
ISSN
1738-3684
Abstract
Objective Although bipolar II disorder (BD II) is not simply a mitigated form of bipolar I disorder (BD I), their neurobiological differ-ences have not been elucidated. The present study aimed to explore cortical thickness (CT) and surface area (SA) in patients with BD I and BD II and healthy controls (HCs) to investigate the shared and unique neurobiological mechanisms of BD subtypes. Methods We enrolled 30 and 44 patients with BD I and BD II, respectively, and 100 HCs. We evaluated CT and SA using FreeSurfer and estimated differences in CT and SA among the three groups (BD I vs. BD II vs. HC). We adjusted for age, sex, educational level, and intracranial volume as confounding factors. Results We found widespread cortical thinning in the bilateral frontal, temporal, and occipital regions; cingulate gyrus; and insula in patients with BD. Alterations in SA, including increased SA of the pars triangularis and decreased SA of the insula, were noted in pa-tients with BD. Overall, we found BD II patients demonstrated decreased SA in the right long insula compared to BD I patients. Conclusion Our results suggest that decreased SA in the right long insula is crucial for differentiating BD subtypes. Psychiatry Investigation 2021;18(9):850-863
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