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Chemical constituents from basidiomycete Basidioradulum radula culture medium and their cytotoxic effect on human prostate cancer DU-145 cells

Authors
Ryu, Seung MokNguyen, Quynh NhuLee, SullimKwon, HaeunKwon, JaeyoungLee, HyaeminKwon, Sun LulLee, JunHwang, Bang YeonYim, Joung-hanGuo, YuanqiangKim, Jae-JinKang, Ki SungLee, Dongho
Issue Date
9월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Basidiomycete; Basidioradulum radula; Cytotoxicity; DU-145 prostate cancer cell; Hyphodermin
Citation
BIOORGANIC CHEMISTRY, v.114
Indexed
SCIE
SCOPUS
Journal Title
BIOORGANIC CHEMISTRY
Volume
114
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136756
DOI
10.1016/j.bioorg.2021.105064
ISSN
0045-2068
Abstract
Eight new naphtho [1,2-c]furan derivatives (1-8) along with six known analogues (9-14) were isolated from culture medium of the basidiomycete Basidioradulum radula. The structures of these compounds were identified using spectroscopic analysis, and their absolute configurations were resolved using X ray diffraction, ECD, and VCD. Compounds 7 and 14 inhibited the cell viability of human prostate cancer DU 145 cells with IC50 values of 7.54 +/- 0.03 mu M and 5.04 +/- 0.03 mu M, respectively. At 8 mu M, compounds 7 and 14 increased the percentage of apoptotic cells and upregulated the protein expression related to the apoptosis caspase pathways in DU 145 cells. Furthermore, the hallmarks of cells undergoing apoptosis, such as chromatin condensation, were also observed at this concentration. However, compound 7 and 14 showed no effect on the proliferation of splenocytes isolated from cyclophosphamide-induce immunosuppressed mice.
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College of Life Sciences and Biotechnology > Division of Environmental Science and Ecological Engineering > 1. Journal Articles
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