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Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian

Authors
An, MiraeOh, MiaePark, Keun-TaeSeon, Ki HwanJo, Jeong EunLee, Seong KweonKim, Jeong-KeunShin, Kwang SoonKoh, Jong-HoLim, Young-Hee
Issue Date
9월-2021
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Keywords
Anti-asthma; Anti-inflammation; Antitussive; Fermented extract of medicinal plant
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.30, no.9, pp.1257 - 1268
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
Volume
30
Number
9
Start Page
1257
End Page
1268
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136777
DOI
10.1007/s10068-021-00955-3
ISSN
1226-7708
Abstract
Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.
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LIM, YOUNG HEE
보건과학대학 (바이오시스템의과학부)
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