Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations
DC Field | Value | Language |
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dc.contributor.author | Hong, Myunghee | - |
dc.contributor.author | Ebana, Yusuke | - |
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Choi, Eue-Keun | - |
dc.contributor.author | Lim, Hong Euy | - |
dc.contributor.author | Hwang, Inseok | - |
dc.contributor.author | Yu, Hee Tae | - |
dc.contributor.author | Kim, Tae-Hoon | - |
dc.contributor.author | Uhm, Jae-Sun | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Lee, Moon-Hyoung | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Jee, Sun Ha | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.date.accessioned | 2022-02-24T21:41:12Z | - |
dc.date.available | 2022-02-24T21:41:12Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0014-2972 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136788 | - |
dc.description.abstract | Background: In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations. Methods: We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population. Results: Among remaining 74 loci, 29 loci were replicated at a P<.05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5x10(-8) (METTL11B at 1q24, KCNN2 at 5q22 and LRMDA at 10q22), 4 loci at the threshold of the Bonferroni correction of P = 4.5 x 10(-4) similar to 5x10(-8) (KIF3C at 2p23, REEP3, NRBF2 at 10q21, SIRT1, MYPN at 10q21 and CFL2 at 14q13) and 10 SNPs with a P=.05 similar to 4.5 x 10(-4). Among 18 AF loci with a MAF<0.01 in the Far East Asian populations, 2 loci (GATA4 at 8q23 and SGCG at 13q12) were replicated after a fine mapping. Twenty-seven AF loci, including a locus, which had a sufficient sample size to get a power of over 80% (with a type 1 error alpha = 4.5 x 10(-4)), were not replicated in the Far East Asian populations. Conclusions: We newly replicated 19 AF-associated genetic loci in the European descent among the Far East Asian populations. It highlights the extensive sharing of AF genetic risks across Far East Asian populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | COHORT PROFILE | - |
dc.subject | RISK | - |
dc.subject | VARIANTS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | RECURRENCE | - |
dc.subject | COMMON | - |
dc.subject | GATA4 | - |
dc.title | Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.identifier.doi | 10.1111/eci.13584 | - |
dc.identifier.scopusid | 2-s2.0-85105731402 | - |
dc.identifier.wosid | 000650455100001 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v.51, no.9 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | - |
dc.citation.title | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | - |
dc.citation.volume | 51 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | COHORT PROFILE | - |
dc.subject.keywordPlus | COMMON | - |
dc.subject.keywordPlus | GATA4 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordAuthor | Asian | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | genetics | - |
dc.subject.keywordAuthor | genome-wide association study | - |
dc.subject.keywordAuthor | meta-analysis | - |
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