Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations
- Authors
- Hong, Myunghee; Ebana, Yusuke; Shim, Jaemin; Choi, Eue-Keun; Lim, Hong Euy; Hwang, Inseok; Yu, Hee Tae; Kim, Tae-Hoon; Uhm, Jae-Sun; Joung, Boyoung; Oh, Seil; Lee, Moon-Hyoung; Kim, Young-Hoon; Jee, Sun Ha; Pak, Hui-Nam
- Issue Date
- 9월-2021
- Publisher
- WILEY
- Keywords
- Asian; atrial fibrillation; genetics; genome-wide association study; meta-analysis
- Citation
- EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v.51, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Volume
- 51
- Number
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136788
- DOI
- 10.1111/eci.13584
- ISSN
- 0014-2972
- Abstract
- Background: In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations. Methods: We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population. Results: Among remaining 74 loci, 29 loci were replicated at a P<.05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5x10(-8) (METTL11B at 1q24, KCNN2 at 5q22 and LRMDA at 10q22), 4 loci at the threshold of the Bonferroni correction of P = 4.5 x 10(-4) similar to 5x10(-8) (KIF3C at 2p23, REEP3, NRBF2 at 10q21, SIRT1, MYPN at 10q21 and CFL2 at 14q13) and 10 SNPs with a P=.05 similar to 4.5 x 10(-4). Among 18 AF loci with a MAF<0.01 in the Far East Asian populations, 2 loci (GATA4 at 8q23 and SGCG at 13q12) were replicated after a fine mapping. Twenty-seven AF loci, including a locus, which had a sufficient sample size to get a power of over 80% (with a type 1 error alpha = 4.5 x 10(-4)), were not replicated in the Far East Asian populations. Conclusions: We newly replicated 19 AF-associated genetic loci in the European descent among the Far East Asian populations. It highlights the extensive sharing of AF genetic risks across Far East Asian populations.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.