UPF1: From mRNA Surveillance to Protein Quality Control
DC Field | Value | Language |
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dc.contributor.author | Hwang, Hyun Jung | - |
dc.contributor.author | Park, Yeonkyoung | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2022-02-26T16:41:17Z | - |
dc.date.available | 2022-02-26T16:41:17Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137035 | - |
dc.description.abstract | Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant transcripts harboring premature termination codons (PTCs). NMD functions also as a post-transcriptional gene regulatory mechanism by downregulating naturally occurring mRNAs. As NMD is activated only after a ribosome reaches a PTC, PTC-containing mRNAs inevitably produce truncated and potentially misfolded polypeptides as byproducts. To cope with the emergence of misfolded polypeptides, eukaryotic cells have evolved sophisticated mechanisms such as chaperone-mediated protein refolding, rapid degradation of misfolded polypeptides through the ubiquitin-proteasome system, and sequestration of misfolded polypeptides to the aggresome for autophagy-mediated degradation. In this review, we discuss how UPF1, a key NMD factor, contributes to the selective removal of faulty transcripts via NMD at the molecular level. We then highlight recent advances on UPF1-mediated communication between mRNA surveillance and protein quality control. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | NONSENSE-MEDIATED DECAY | - |
dc.subject | EXON JUNCTION COMPLEX | - |
dc.subject | AGGRESOME FORMATION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | TRANSLATION | - |
dc.subject | BINDING | - |
dc.subject | DEGRADATION | - |
dc.subject | UBIQUITIN | - |
dc.subject | HDAC6 | - |
dc.subject | CAP | - |
dc.title | UPF1: From mRNA Surveillance to Protein Quality Control | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.3390/biomedicines9080995 | - |
dc.identifier.scopusid | 2-s2.0-85113156776 | - |
dc.identifier.wosid | 000689002200001 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, v.9, no.8 | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.citation.title | BIOMEDICINES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | AGGRESOME FORMATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CAP | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | EXON JUNCTION COMPLEX | - |
dc.subject.keywordPlus | HDAC6 | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordAuthor | CTIF | - |
dc.subject.keywordAuthor | UPF1 | - |
dc.subject.keywordAuthor | aggresome | - |
dc.subject.keywordAuthor | mRNA surveillance | - |
dc.subject.keywordAuthor | nonsense-mediated mRNA decay | - |
dc.subject.keywordAuthor | protein quality control | - |
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