Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

UPF1: From mRNA Surveillance to Protein Quality Control

Authors
Hwang, Hyun JungPark, YeonkyoungKim, Yoon Ki
Issue Date
8월-2021
Publisher
MDPI
Keywords
CTIF; UPF1; aggresome; mRNA surveillance; nonsense-mediated mRNA decay; protein quality control
Citation
BIOMEDICINES, v.9, no.8
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICINES
Volume
9
Number
8
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137035
DOI
10.3390/biomedicines9080995
ISSN
2227-9059
Abstract
Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant transcripts harboring premature termination codons (PTCs). NMD functions also as a post-transcriptional gene regulatory mechanism by downregulating naturally occurring mRNAs. As NMD is activated only after a ribosome reaches a PTC, PTC-containing mRNAs inevitably produce truncated and potentially misfolded polypeptides as byproducts. To cope with the emergence of misfolded polypeptides, eukaryotic cells have evolved sophisticated mechanisms such as chaperone-mediated protein refolding, rapid degradation of misfolded polypeptides through the ubiquitin-proteasome system, and sequestration of misfolded polypeptides to the aggresome for autophagy-mediated degradation. In this review, we discuss how UPF1, a key NMD factor, contributes to the selective removal of faulty transcripts via NMD at the molecular level. We then highlight recent advances on UPF1-mediated communication between mRNA surveillance and protein quality control.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE