Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong Gyu | - |
dc.contributor.author | Bak, Myeong Seong | - |
dc.contributor.author | Kim, Ahbin | - |
dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Chae, Yun-Cheol | - |
dc.contributor.author | Kim, Ye Lee | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | An, Joon-Yong | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.date.accessioned | 2022-02-27T16:41:26Z | - |
dc.date.available | 2022-02-27T16:41:26Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-07-03 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137156 | - |
dc.description.abstract | Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b(+/-)) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b(+/-) mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b(+/-) mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | HISTONE METHYLATION | - |
dc.subject | PROTEIN-SYNTHESIS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | COMPLEXIN-II | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | ACTIVATION | - |
dc.subject | PLASTICITY | - |
dc.subject | KNOCKOUT | - |
dc.subject | RECEPTOR | - |
dc.subject | AMYGDALA | - |
dc.title | Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Joon-Yong | - |
dc.identifier.doi | 10.1186/s13041-021-00815-5 | - |
dc.identifier.scopusid | 2-s2.0-85108989702 | - |
dc.identifier.wosid | 000671948000002 | - |
dc.identifier.bibliographicCitation | MOLECULAR BRAIN, v.14, no.1 | - |
dc.relation.isPartOf | MOLECULAR BRAIN | - |
dc.citation.title | MOLECULAR BRAIN | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AMYGDALA | - |
dc.subject.keywordPlus | COMPLEXIN-II | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | HISTONE METHYLATION | - |
dc.subject.keywordPlus | KNOCKOUT | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Cerebellum | - |
dc.subject.keywordAuthor | Histone modification | - |
dc.subject.keywordAuthor | Kdm3b | - |
dc.subject.keywordAuthor | Optokinetic response (OKR) | - |
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