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Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice

Authors
Kim, Yong GyuBak, Myeong SeongKim, AhbinKim, YujinChae, Yun-CheolKim, Ye LeeChun, Yang-SookAn, Joon-YongSeo, Sang-BeomKim, Sang JeongLee, Yong-Seok
Issue Date
3-7월-2021
Publisher
BMC
Keywords
Cerebellum; Histone modification; Kdm3b; Optokinetic response (OKR)
Citation
MOLECULAR BRAIN, v.14, no.1
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR BRAIN
Volume
14
Number
1
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137156
DOI
10.1186/s13041-021-00815-5
ISSN
1756-6606
Abstract
Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b(+/-)) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b(+/-) mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b(+/-) mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory.
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