Differential Factors for Predicting Outcomes in Left Main versus Non-Left Main Coronary Bifurcation Stenting
- Authors
- Cha, Jung-Joon; Hong, Soon Jun; Joo, Hyung Joon; Park, Jae Hyoung; Yu, Cheol Woong; Ahn, Tae Hoon; Kim, Hyo-Soo; Chun, Woo Jung; Hur, Seung-Ho; Han, Seung Hwan; Rha, Seung-Woon; Chae, In-Ho; Jeong, Jin-Ok; Heo, Jung Ho; Yoon, Junghan; Choi, Ki Hong; Song, Young Bin; Gwon, Hyeon-Cheol; Park, Jong-Seon; Hong, Myeong-Ki; Doh, Joon-Hyung; Cha, Kwang Soo; Kim, Doo-Il; Lee, Sang Yeub; Chang, Kiyuk; Hwang, Byung-Hee; Choi, So-Yeon; Jeong, Myung Ho; Nam, Chang-Wook; Koo, Bon-Kwon; Lim, Do-Sun
- Issue Date
- Jul-2021
- Publisher
- MDPI
- Keywords
- clinical outcome; coronary bifurcation stenting; drug-eluting stents; predictor
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.10, no.14
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 10
- Number
- 14
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137185
- DOI
- 10.3390/jcm10143024
- ISSN
- 2077-0383
- Abstract
- Background: No large-scale study has compared the clinical and angiographic predictors of cardiovascular events in patients with left main bifurcation (LMB) and non-LMB stenting after second-generation DES implantation. Herein, we investigated differential clinical and angiographic factors for predicting outcomes in LMB versus non-LMB stenting. Methods: A total of 2648 patients with bifurcation lesions treated with second-generation DESs from the retrospective patient cohort were divided into an LMB group (n = 935) and a non-LMB group (n = 1713). The primary outcome was the 7-year incidence of target lesion failure (TLF), defined as the composite of cardiac death, myocardial infarction, and target lesion revascularization. Results: The incidence of TLF was 9.8%. Those in the LMB group were associated with a higher risk of TLF (14.2% versus 7.5%, p < 0.001) than those in the non-LMB group. Regarding the LMB group, independent predictors of TLF were chronic kidney disease (CKD), reduced left ventricular ejection fraction (LVEF), and two-stenting. Regarding the non-LMB group, CKD, reduced LVEF, old age, diabetes, and small diameter of the main vessel stent were independent predictors of TLF. Conclusions: The two-stent strategy could potentially increase TLF for the LMB lesions, and achieving the maximal diameter of the main vessel stent could result in better clinical outcomes for non-LMB lesions.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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