Immunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvant
- Authors
- Han, Jeong Moo; Song, Ha-Yeon; Seo, Ho Seong; Byun, Eui-Hong; Lim, Seung-Taik; Kim, Woo Sik; Byun, Eui-Baek
- Issue Date
- Jun-2021
- Publisher
- ELSEVIER
- Keywords
- Adjuvant; Anti-tumor immunity; Chrysanthemum zawadskii Herbich var; Dendritic cell; Natural product; Polyfunctional T cell; latilobum
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.95
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 95
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137318
- DOI
- 10.1016/j.intimp.2021.107513
- ISSN
- 1567-5769
- Abstract
- The objective of the current study was to demonstrate the immunostimulatory effects of a polysaccharide isolated from Chrysanthemum zawadskii Herbich var. latilobum leaves (CP) and evaluate its potential as a vaccine adjuvant. Results showed that CP induced maturation of the dendritic cells (DCs). In addition, CP-treated DCs activated naive T cells to polarized CD4+ and CD8+ T cells and substantially induced the production of IFN-gamma and IL-2 in vitro. Furthermore, CP initiated the maturation of DCs via the activation of MAPK and NF-xB signaling pathways. Interestingly, systemic administration of CP-treated DCs pulsed with ovalbumin (OVA) peptides significantly enhanced the immune response in vivo, which included the generation of antigen (OVA)-specific polyfunctional T cells, increased cytotoxic T lymphocyte activity, induction of Th1-mediated humoral immunity, and suppression of tumor growth. Taken together, our study highlighted the immunoregulatory activity of CP as well as its potential as a candidate vaccine adjuvant.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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