Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells
DC Field | Value | Language |
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dc.contributor.author | Yang, Jiyoon | - |
dc.contributor.author | Choi, Won-Sil | - |
dc.contributor.author | Kim, Ki-Joong | - |
dc.contributor.author | Eom, Chang-Deuk | - |
dc.contributor.author | Park, Mi-Jin | - |
dc.date.accessioned | 2022-03-01T05:41:44Z | - |
dc.date.available | 2022-03-01T05:41:44Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137338 | - |
dc.description.abstract | In a previous study, we demonstrated the anti-inflammatory activity of the essential oil extracted from Korean pine (Pinus koraiensis, Sieb. et Zucc.) wood. This study aims to investigate the active anti-inflammatory constituents of P. koraiensis oil. The essential oil was extracted from P. koraiensis wood by hydrodistillation and was divided into six fractions (A-F) through fractional distillation. Then, the anti-inflammatory activities of the fractions (A-F) were determined. Fractions A and F markedly downregulated the production of pro-inflammatory cytokines as well as the secretion of beta-hexosaminidase in lipopolysaccharide (LPS)-stimulated RBL-2H3 cells. The main constituents of the active anti-inflammatory A and F fractions were (+)-alpha-pinene, (-)-beta-pinene, (+)-alpha-terpineol, 3-carene, (+)-limonene, and longifolene. These six single compounds decreased the expression of inflammatory-related genes (i.e., IL-4 and IL-13) as well as the secretion of beta-hexosaminidase in LPS-stimulated RBL-2H3 cells. (+)-alpha-Pinene, (-)-beta-pinene, (+)-alpha-terpineol, and longifolene exhibited the strongest effects; these effects were comparable to those of the positive control (i.e., dexamethasone). The findings indicate that the interactions between these components exhibit potential for the management and/or treatment of inflammatory conditions as well as base structures for the development of novel anti-inflammatory drugs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ALPHA-TERPINEOL | - |
dc.subject | IL-13 | - |
dc.subject | CYTOKINES | - |
dc.title | Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Joong | - |
dc.identifier.doi | 10.3390/biom11060817 | - |
dc.identifier.scopusid | 2-s2.0-85106756548 | - |
dc.identifier.wosid | 000665295800001 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.11, no.6 | - |
dc.relation.isPartOf | BIOMOLECULES | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 11 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | ALPHA-TERPINEOL | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | IL-13 | - |
dc.subject.keywordAuthor | Pinus koraiensis | - |
dc.subject.keywordAuthor | active compound | - |
dc.subject.keywordAuthor | alpha-pinene | - |
dc.subject.keywordAuthor | alpha-terpineol | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | beta-pinene | - |
dc.subject.keywordAuthor | essential oil | - |
dc.subject.keywordAuthor | longifolene | - |
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