Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells
- Authors
- Yang, Jiyoon; Choi, Won-Sil; Kim, Ki-Joong; Eom, Chang-Deuk; Park, Mi-Jin
- Issue Date
- 6월-2021
- Publisher
- MDPI
- Keywords
- Pinus koraiensis; active compound; alpha-pinene; alpha-terpineol; anti-inflammatory; beta-pinene; essential oil; longifolene
- Citation
- BIOMOLECULES, v.11, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMOLECULES
- Volume
- 11
- Number
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137338
- DOI
- 10.3390/biom11060817
- ISSN
- 2218-273X
- Abstract
- In a previous study, we demonstrated the anti-inflammatory activity of the essential oil extracted from Korean pine (Pinus koraiensis, Sieb. et Zucc.) wood. This study aims to investigate the active anti-inflammatory constituents of P. koraiensis oil. The essential oil was extracted from P. koraiensis wood by hydrodistillation and was divided into six fractions (A-F) through fractional distillation. Then, the anti-inflammatory activities of the fractions (A-F) were determined. Fractions A and F markedly downregulated the production of pro-inflammatory cytokines as well as the secretion of beta-hexosaminidase in lipopolysaccharide (LPS)-stimulated RBL-2H3 cells. The main constituents of the active anti-inflammatory A and F fractions were (+)-alpha-pinene, (-)-beta-pinene, (+)-alpha-terpineol, 3-carene, (+)-limonene, and longifolene. These six single compounds decreased the expression of inflammatory-related genes (i.e., IL-4 and IL-13) as well as the secretion of beta-hexosaminidase in LPS-stimulated RBL-2H3 cells. (+)-alpha-Pinene, (-)-beta-pinene, (+)-alpha-terpineol, and longifolene exhibited the strongest effects; these effects were comparable to those of the positive control (i.e., dexamethasone). The findings indicate that the interactions between these components exhibit potential for the management and/or treatment of inflammatory conditions as well as base structures for the development of novel anti-inflammatory drugs.
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