Mesenchymal stem cells and platelet-rich plasma-impregnated polycaprolactone-beta tricalcium phosphate bio-scaffold enhanced bone regeneration around dental implants
- Authors
- Almansoori, Akram Abdo; Kwon, Oh-Jun; Nam, Jeong-Hun; Seo, Young-Kwon; Song, Hae-Ryong; Lee, Jong-Ho
- Issue Date
- 5-May-2021
- Publisher
- SPRINGER JAPAN KK
- Keywords
- & #946; -Tricalcium phosphate; Dental implants; Guided bone regeneration; Mesenchymal stem cells; Platelet-rich plasma; Polycaprolactone
- Citation
- INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY, v.7, no.1
- Indexed
- SCIE
- Journal Title
- INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
- Volume
- 7
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137389
- DOI
- 10.1186/s40729-021-00317-y
- ISSN
- 2198-4034
- Abstract
- Background Finding a material that supports bone regeneration is the concern for many investigators. We supposed that a composite scaffold of poly(epsilon) caprolactone and beta-tricalcium phosphate (PCL-TCP) would entail desirable characteristics of biocompatibility, bioresorbability, rigidity, and osteoconductivity for a proper guided bone regeneration. Furthermore, the incorporation of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) would boost the bone regeneration. We conducted this study to evaluate the bone regeneration capacity of PCL-TCP scaffold that is loaded with MSCs and PRP. Materials and methods Five miniature pigs received 6 implants in 6 created-mandibular bony defects in the right and left lower premolar areas. The bony defects were managed according to the following three groups: the PCL-TCP scaffold loaded with MSCs and PRP (MSCs+PRP+PCL-TCP) group (n = 10), PCL-TCP scaffold loaded with PRP (PRP+PCL-TCP) group (n = 10), and PCL-TCP scaffold group (n = 10). After 12 weeks, the bone regeneration was assessed using fluorochrome bone labeling, mu CT bone morphogenic analysis, and histomorphometric analysis. Results All of the three groups supported the bone regeneration around the dental implants. However, the PCL-TCP scaffold loaded with MSCs and PRP (MSCs+PRP+PCL-TCP) group showed non-significant higher bone surface, bone specific surface, and bone surface density than the other two groups as revealed by the mu CT bone morphogenic analysis. Histologically, the same group revealed higher bone-implant contact ratio (BIC) (p = 0.017) and new bone height formation (NBH, mm) (p = 0.0097) with statistically significant difference compared to the PCL-TCP scaffold group. Conclusions PCL-TCP scaffold is compatible for bone regeneration in bone defects surrounding dental implants. Moreover, the incorporation of MSCs and PRP optimized the bone regeneration process with respect to the rate of scaffold replacement, the height of the regenerated bone, and implant stability.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/137389)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.