Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, Jiah | - |
dc.contributor.author | Ma, Seongho | - |
dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Lim, Young-Hee | - |
dc.date.accessioned | 2022-03-02T00:41:52Z | - |
dc.date.available | 2022-03-02T00:41:52Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137433 | - |
dc.description.abstract | Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. The aim of this study was to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis. OXY ameliorated DSS-induced colitis and repaired damaged intestinal mucosa. OXY downregulated the expression of pro-inflammatory cytokine genes (TNF-alpha, IL-6, and IL-1 beta) and chemokine gene MCP-1, while promoting the production of anti-inflammatory cytokine IL-10. OXY treatment also suppressed inflammation via inhibiting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in the colon, as well as the activity of myeloperoxidase (MPO). OXY exhibited anti-apoptotic effects, shifting the Bax/Bcl-2 balance. In conclusion, OXY might improve DSS-induced colitis by restoring the intestinal mucus layer and reducing inflammation within the intestine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | BOWEL-DISEASE | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | PATHOGENESIS | - |
dc.subject | RESVERATROL | - |
dc.subject | APOPTOSIS | - |
dc.subject | MODEL | - |
dc.title | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hee | - |
dc.identifier.doi | 10.3390/molecules26092630 | - |
dc.identifier.scopusid | 2-s2.0-85105478469 | - |
dc.identifier.wosid | 000650721700001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.26, no.9 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 26 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | intestinal mucus layer | - |
dc.subject.keywordAuthor | oxyresveratrol | - |
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