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Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation

Authors
Yeom, JiahMa, SeonghoKim, Jeong-KeunLim, Young-Hee
Issue Date
5월-2021
Publisher
MDPI
Keywords
anti-inflammatory; colitis; intestinal mucus layer; oxyresveratrol
Citation
MOLECULES, v.26, no.9
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
26
Number
9
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137433
DOI
10.3390/molecules26092630
ISSN
1420-3049
Abstract
Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. The aim of this study was to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis. OXY ameliorated DSS-induced colitis and repaired damaged intestinal mucosa. OXY downregulated the expression of pro-inflammatory cytokine genes (TNF-alpha, IL-6, and IL-1 beta) and chemokine gene MCP-1, while promoting the production of anti-inflammatory cytokine IL-10. OXY treatment also suppressed inflammation via inhibiting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in the colon, as well as the activity of myeloperoxidase (MPO). OXY exhibited anti-apoptotic effects, shifting the Bax/Bcl-2 balance. In conclusion, OXY might improve DSS-induced colitis by restoring the intestinal mucus layer and reducing inflammation within the intestine.
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LIM, YOUNG HEE
보건과학대학 (바이오시스템의과학부)
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