Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics
DC Field | Value | Language |
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dc.contributor.author | Jeong, Keunsoo | - |
dc.contributor.author | Kim, Dojin | - |
dc.contributor.author | Kim, Hyun Jun | - |
dc.contributor.author | Lee, Yong-Deok | - |
dc.contributor.author | Yoo, Jounghyun | - |
dc.contributor.author | Jang, Dohyub | - |
dc.contributor.author | Lee, Seokyung | - |
dc.contributor.author | Park, Hyeonjong | - |
dc.contributor.author | Kim, Youngsun | - |
dc.contributor.author | Singh, Ajay | - |
dc.contributor.author | Ahn, Dong June | - |
dc.contributor.author | Kim, Dong Ha | - |
dc.contributor.author | Bang, Joona | - |
dc.contributor.author | Kim, Jungahn | - |
dc.contributor.author | Prasad, Paras N. | - |
dc.contributor.author | Kim, Sehoon | - |
dc.date.accessioned | 2022-03-03T16:40:39Z | - |
dc.date.available | 2022-03-03T16:40:39Z | - |
dc.date.created | 2022-03-02 | - |
dc.date.issued | 2021-11-23 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137641 | - |
dc.description.abstract | Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | IN-VIVO | - |
dc.subject | GOLD NANORODS | - |
dc.subject | CORE/SHELL NANOPARTICLES | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | PROTECTING GROUPS | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | ULTRASOUND | - |
dc.subject | DRUG | - |
dc.subject | THERAPY | - |
dc.subject | GENE | - |
dc.title | Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, Joona | - |
dc.identifier.doi | 10.1021/acsnano.1c07898 | - |
dc.identifier.scopusid | 2-s2.0-85117294031 | - |
dc.identifier.wosid | 000747115200114 | - |
dc.identifier.bibliographicCitation | ACS NANO, v.15, no.11, pp.18394 - 18402 | - |
dc.relation.isPartOf | ACS NANO | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 15 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 18394 | - |
dc.citation.endPage | 18402 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GOLD NANORODS | - |
dc.subject.keywordPlus | CORE/SHELL NANOPARTICLES | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | PROTECTING GROUPS | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | ultrasound | - |
dc.subject.keywordAuthor | upconversion | - |
dc.subject.keywordAuthor | near-infrared | - |
dc.subject.keywordAuthor | microbubble | - |
dc.subject.keywordAuthor | nanohybrid | - |
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