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Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics

Authors
Jeong, KeunsooKim, DojinKim, Hyun JunLee, Yong-DeokYoo, JounghyunJang, DohyubLee, SeokyungPark, HyeonjongKim, YoungsunSingh, AjayAhn, Dong JuneKim, Dong HaBang, JoonaKim, JungahnPrasad, Paras N.Kim, Sehoon
Issue Date
23-11월-2021
Publisher
AMER CHEMICAL SOC
Keywords
ultrasound; upconversion; near-infrared; microbubble; nanohybrid
Citation
ACS NANO, v.15, no.11, pp.18394 - 18402
Indexed
SCIE
SCOPUS
Journal Title
ACS NANO
Volume
15
Number
11
Start Page
18394
End Page
18402
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137641
DOI
10.1021/acsnano.1c07898
ISSN
1936-0851
Abstract
Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics.
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