TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-kappa B signaling pathway in macrophages
DC Field | Value | Language |
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dc.contributor.author | Roh, Kyung-Hye | - |
dc.contributor.author | Lee, Yeojin | - |
dc.contributor.author | Yoon, Je-Hyun | - |
dc.contributor.author | Lee, Danbi | - |
dc.contributor.author | Kim, Eunju | - |
dc.contributor.author | Park, Eunchong | - |
dc.contributor.author | Lee, In Young | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Shin, Jaekyoon | - |
dc.contributor.author | Lim, Dae-Sik | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.date.accessioned | 2022-03-04T18:40:44Z | - |
dc.date.available | 2022-03-04T18:40:44Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137771 | - |
dc.description.abstract | Pattern-recognition receptors including Toll-like receptors (TLRs) recognize invading pathogens and trigger an immune response in mammals. Here we show that mammalian ste20-like kinase 1/serine/threonine kinase 4 (MST1/STK4) functions as a negative regulator of lipopolysaccharide (LPS)-induced activation of the TLR4-NF-kappa B signaling pathway associated with inflammation. Myeloid-specific genetic ablation of MST1/STK4 increased the susceptibility of mice to LPS-induced septic shock. Ablation of MST1/STK4 also enhanced NF-kappa B activation triggered by LPS in bone marrow-derived macrophages (BMDMs), leading to increased production of proinflammatory cytokines by these cells. Furthermore, MST1/STK4 inhibited TRAF6 autoubiquitination as well as TRAF6-mediated downstream signaling induced by LPS. In addition, we found that TRAF6 mediates the LPS-induced activation of MST1/STK4 by catalyzing its ubiquitination, resulting in negative feedback regulation by MST1/STK4 of the LPS-induced pathway leading to cytokine production in macrophages. Together, our findings suggest that MST1/STK4 functions as a negative modulator of the LPS-induced NF-kappa B signaling pathway during macrophage activation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | INTERACTING PROTEIN P62 | - |
dc.subject | NEGATIVE REGULATION | - |
dc.subject | IMPORTANT MEDIATOR | - |
dc.subject | MST1 KINASE | - |
dc.subject | ADAPTER P62 | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | TRAF6 | - |
dc.subject | IDENTIFICATION | - |
dc.title | TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-kappa B signaling pathway in macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.identifier.doi | 10.1007/s00018-020-03650-4 | - |
dc.identifier.scopusid | 2-s2.0-85091409057 | - |
dc.identifier.wosid | 000572730100001 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, v.78, no.5, pp.2315 - 2328 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.title | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.volume | 78 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2315 | - |
dc.citation.endPage | 2328 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ADAPTER P62 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | IMPORTANT MEDIATOR | - |
dc.subject.keywordPlus | INTERACTING PROTEIN P62 | - |
dc.subject.keywordPlus | MST1 KINASE | - |
dc.subject.keywordPlus | NEGATIVE REGULATION | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TRAF6 | - |
dc.subject.keywordAuthor | Lipopolysaccharides | - |
dc.subject.keywordAuthor | MST1/STK4 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | TRAF6 | - |
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