Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-kappa B signaling pathway in macrophages

Authors
Roh, Kyung-HyeLee, YeojinYoon, Je-HyunLee, DanbiKim, EunjuPark, EunchongLee, In YoungKim, Tae SungSong, Hyun KyuShin, JaekyoonLim, Dae-SikChoi, Eui-Ju
Issue Date
3월-2021
Publisher
SPRINGER BASEL AG
Keywords
Lipopolysaccharides; MST1/STK4; NF-kappa B; TRAF6
Citation
CELLULAR AND MOLECULAR LIFE SCIENCES, v.78, no.5, pp.2315 - 2328
Indexed
SCIE
SCOPUS
Journal Title
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume
78
Number
5
Start Page
2315
End Page
2328
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137771
DOI
10.1007/s00018-020-03650-4
ISSN
1420-682X
Abstract
Pattern-recognition receptors including Toll-like receptors (TLRs) recognize invading pathogens and trigger an immune response in mammals. Here we show that mammalian ste20-like kinase 1/serine/threonine kinase 4 (MST1/STK4) functions as a negative regulator of lipopolysaccharide (LPS)-induced activation of the TLR4-NF-kappa B signaling pathway associated with inflammation. Myeloid-specific genetic ablation of MST1/STK4 increased the susceptibility of mice to LPS-induced septic shock. Ablation of MST1/STK4 also enhanced NF-kappa B activation triggered by LPS in bone marrow-derived macrophages (BMDMs), leading to increased production of proinflammatory cytokines by these cells. Furthermore, MST1/STK4 inhibited TRAF6 autoubiquitination as well as TRAF6-mediated downstream signaling induced by LPS. In addition, we found that TRAF6 mediates the LPS-induced activation of MST1/STK4 by catalyzing its ubiquitination, resulting in negative feedback regulation by MST1/STK4 of the LPS-induced pathway leading to cytokine production in macrophages. Together, our findings suggest that MST1/STK4 functions as a negative modulator of the LPS-induced NF-kappa B signaling pathway during macrophage activation.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE