Tetrahydroprotoberberine N-oxides from Chelidonium majus and their inhibitory effects on NO production in RAW 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | Le, Thi Phuong Linh | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.contributor.author | Kim, Jun Gu | - |
dc.contributor.author | Han, Jae Sang | - |
dc.contributor.author | Kwon, Haeun | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.date.accessioned | 2022-03-05T00:40:18Z | - |
dc.date.available | 2022-03-05T00:40:18Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 1874-3900 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137799 | - |
dc.description.abstract | Two new tetrahydroprotoberberine N-oxides, 7R,14S-cis-tetrahydrocoptisine N-oxide (1) and 7R,14R-trans-tetrahydmeoptisine N-oxide (2) along with fourteen known compounds (3-16) were isolated from the aerial parts of Chelidonium mails. Their structures were elucidated by spectroscopic and spectrometric methods, such as 1D and 2D-NMR (HSQC, HMBC, NOESY) and HRESIMS. The absolute configurations of 1 and 2 were established by comparison of their experimental and calculated ECD data. All isolates were evaluated for their inhibitory effects on the nitric oxide production in LPS-induced RAW 264.7 macrophages, and compounds 2, 6-10, 13, and 15 showed significant inhibitory effects with the IC50 values ranging from 1.1-31.9 mu M. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | INFLAMMATORY MEDIATORS | - |
dc.subject | KAPPA-B | - |
dc.subject | ALKALOIDS | - |
dc.subject | CONSTITUENTS | - |
dc.subject | BENZOPHENANTHRIDINE | - |
dc.subject | L. | - |
dc.subject | PAPAVERACEAE | - |
dc.subject | DERIVATIVES | - |
dc.subject | ANTITUMOR | - |
dc.subject | ACID | - |
dc.title | Tetrahydroprotoberberine N-oxides from Chelidonium majus and their inhibitory effects on NO production in RAW 264.7 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1016/j.phytol.2020.10.014 | - |
dc.identifier.scopusid | 2-s2.0-85095435141 | - |
dc.identifier.wosid | 000697281100007 | - |
dc.identifier.bibliographicCitation | PHYTOCHEMISTRY LETTERS, v.41, pp.38 - 42 | - |
dc.relation.isPartOf | PHYTOCHEMISTRY LETTERS | - |
dc.citation.title | PHYTOCHEMISTRY LETTERS | - |
dc.citation.volume | 41 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 42 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | INFLAMMATORY MEDIATORS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | ALKALOIDS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | BENZOPHENANTHRIDINE | - |
dc.subject.keywordPlus | L. | - |
dc.subject.keywordPlus | PAPAVERACEAE | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Chelidonium majus | - |
dc.subject.keywordAuthor | Papaveraceae | - |
dc.subject.keywordAuthor | Nitric oxide, tetrahydrocoptisine N-oxide | - |
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