Tetrahydroprotoberberine N-oxides from Chelidonium majus and their inhibitory effects on NO production in RAW 264.7 cells
- Authors
- Le, Thi Phuong Linh; Lee, Jin Woo; Kim, Jun Gu; Han, Jae Sang; Kwon, Haeun; Lee, Dongho; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 2월-2021
- Publisher
- ELSEVIER
- Keywords
- Chelidonium majus; Papaveraceae; Nitric oxide, tetrahydrocoptisine N-oxide
- Citation
- PHYTOCHEMISTRY LETTERS, v.41, pp.38 - 42
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOCHEMISTRY LETTERS
- Volume
- 41
- Start Page
- 38
- End Page
- 42
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137799
- DOI
- 10.1016/j.phytol.2020.10.014
- ISSN
- 1874-3900
- Abstract
- Two new tetrahydroprotoberberine N-oxides, 7R,14S-cis-tetrahydrocoptisine N-oxide (1) and 7R,14R-trans-tetrahydmeoptisine N-oxide (2) along with fourteen known compounds (3-16) were isolated from the aerial parts of Chelidonium mails. Their structures were elucidated by spectroscopic and spectrometric methods, such as 1D and 2D-NMR (HSQC, HMBC, NOESY) and HRESIMS. The absolute configurations of 1 and 2 were established by comparison of their experimental and calculated ECD data. All isolates were evaluated for their inhibitory effects on the nitric oxide production in LPS-induced RAW 264.7 macrophages, and compounds 2, 6-10, 13, and 15 showed significant inhibitory effects with the IC50 values ranging from 1.1-31.9 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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