Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model
DC Field | Value | Language |
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dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Han, Sung Hee | - |
dc.contributor.author | Kim, Min Guk | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Kim, Woo Jung | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Jo, Kyungae | - |
dc.date.accessioned | 2022-03-05T03:40:54Z | - |
dc.date.available | 2022-03-05T03:40:54Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-01-01 | - |
dc.identifier.issn | 1388-0209 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137816 | - |
dc.description.abstract | Context Depression is a severe mental illness caused by a deficiency of dopamine and serotonin. Cannabis sativa L. (Cannabaceae) has long been used to treat pain, nausea, and depression. Objective This study investigates the anti-depressant effects of C. sativa (hemp) seed ethanol extract (HE) in chlorpromazine (CPZ)-induced Drosophila melanogaster depression model. Materials and methods The normal group was untreated, and the control group was treated with CPZ (0.1% of media) for 7 days. The experimental groups were treated with a single HE treatment (0.5, 1.0, and 1.5% of media) and a mixture of 0.1% CPZ and HE for 7 days. The locomotor activity, behavioural patterns, depression-related gene expression, and neurotransmitters level of flies were investigated. Results The behavioural patterns of individual flies were significantly reduced with 0.1% CPZ treatment. In contrast, combination treatment of 1.5% HE and 0.1% CPZ significantly increased subjective daytime activity (p < 0.001) and behavioural factors (p < 0.001). These results correlate with increased transcript levels of dopamine (p < 0.001) and serotonin (p < 0.05) receptors and concentration of dopamine (p < 0.05), levodopa (p < 0.001), 5-HTP (p < 0.05), and serotonin (p < 0.001) compared to those in the control group. Discussion and conclusions Collectively, HE administration alleviates depression-like symptoms by modulating the circadian rhythm-related behaviours, transcript levels of neurotransmitter receptors, and neurotransmitter levels in the CPZ-induced Drosophila model. However, additional research is needed to investigate the role of HE administration in behavioural patterns, reduction of the neurotransmitter, and signalling pathways of depression in a vertebrate model system. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | ANTIDEPRESSANT-LIKE | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | DOPAMINE | - |
dc.subject | STRESS | - |
dc.subject | INVOLVEMENT | - |
dc.subject | NEUROBIOLOGY | - |
dc.subject | MECHANISMS | - |
dc.subject | SEROTONIN | - |
dc.subject | INSIGHTS | - |
dc.subject | ORGANISM | - |
dc.title | Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1080/13880209.2021.1949356 | - |
dc.identifier.scopusid | 2-s2.0-85112490125 | - |
dc.identifier.wosid | 000682349300001 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL BIOLOGY, v.59, no.1, pp.998 - 1007 | - |
dc.relation.isPartOf | PHARMACEUTICAL BIOLOGY | - |
dc.citation.title | PHARMACEUTICAL BIOLOGY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 998 | - |
dc.citation.endPage | 1007 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTIDEPRESSANT-LIKE | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | NEUROBIOLOGY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | ORGANISM | - |
dc.subject.keywordAuthor | Behavioural pattern | - |
dc.subject.keywordAuthor | cannabinoid | - |
dc.subject.keywordAuthor | neurotransmitter | - |
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