Effects of trabecular meshwork width and schlemm's canal area on intraocular pressure reduction in glaucoma patients
DC Field | Value | Language |
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dc.contributor.author | Chung, H.W. | - |
dc.contributor.author | Park, J.-H. | - |
dc.contributor.author | Yoo, C. | - |
dc.contributor.author | Kim, Y.Y. | - |
dc.date.accessioned | 2022-03-09T23:41:52Z | - |
dc.date.available | 2022-03-09T23:41:52Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1011-8942 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138401 | - |
dc.description.abstract | Purpose: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm's canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG). Methods: A total 69 eyes of POAG patients who had not been treated with IOP-lowering agent were enrolled in this retrospective study. The patients had been prescribed topical IOP-lowering agent and used it for 1 year. The morphologic features of the TM and SC were collected using anterior segment module of spectral-domain optical coherence tomography with enhanced depth imaging at baseline. Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. We investigated the effects of baseline TM and SC microstructures on IOP reduction amount. Results: The baseline IOP of 69 glaucomatous eyes was 17.9 ± 3.8 mmHg, and the mean amount of IOP reduction was 3.5 ± 2.1 mmHg after 1 year. Mean TM widths of nasal and temporal sector were 470.33 ± 80.05 and 479.74 ± 79.59 μm, respectively. SC area was measured as 4,818.50 ± 1,464.28, 4,604.23 ± 1,567.73 μm2 at nasal sector and temporal sector, respectively. The correlation analysis revealed a positive correlation between SC area and average amount of IOP reduction, indicating that the larger baseline SC area, the greater the IOP drop with topical IOP-lowering agents. However, no correlation was found between TM width and IOP lowering amount in patients with POAG. Conclusions: The baseline SC area showed positive correlation with the IOP reduction amount in patients with POAG. This finding suggests that the SC area can be a clinical parameter to predict the IOP reduction amount before using IOP-lowering agents in POAG patient. © Korean Journal of Ophthalmology 2021. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Ophthalmological Society (KOS) | - |
dc.title | Effects of trabecular meshwork width and schlemm's canal area on intraocular pressure reduction in glaucoma patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, J.-H. | - |
dc.contributor.affiliatedAuthor | Yoo, C. | - |
dc.identifier.doi | 10.3341/kjo.2021.0007 | - |
dc.identifier.scopusid | 2-s2.0-85112268565 | - |
dc.identifier.bibliographicCitation | Korean Journal of Ophthalmology, v.35, no.4, pp.311 - 317 | - |
dc.relation.isPartOf | Korean Journal of Ophthalmology | - |
dc.citation.title | Korean Journal of Ophthalmology | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 317 | - |
dc.type.rims | ART | - |
dc.type.docType | Conference Paper | - |
dc.identifier.kciid | ART002743097 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Anterior segment optical coherence tomography | - |
dc.subject.keywordAuthor | Aqueous outflow | - |
dc.subject.keywordAuthor | Glaucoma | - |
dc.subject.keywordAuthor | Schlemm&apos | - |
dc.subject.keywordAuthor | s canal | - |
dc.subject.keywordAuthor | Trabecular meshwork | - |
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