Effects of trabecular meshwork width and schlemm's canal area on intraocular pressure reduction in glaucoma patients
- Authors
- Chung, H.W.; Park, J.-H.; Yoo, C.; Kim, Y.Y.
- Issue Date
- 2021
- Publisher
- Korean Ophthalmological Society (KOS)
- Keywords
- Anterior segment optical coherence tomography; Aqueous outflow; Glaucoma; Schlemm' s canal; Trabecular meshwork
- Citation
- Korean Journal of Ophthalmology, v.35, no.4, pp.311 - 317
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Ophthalmology
- Volume
- 35
- Number
- 4
- Start Page
- 311
- End Page
- 317
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/138401
- DOI
- 10.3341/kjo.2021.0007
- ISSN
- 1011-8942
- Abstract
- Purpose: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm's canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG). Methods: A total 69 eyes of POAG patients who had not been treated with IOP-lowering agent were enrolled in this retrospective study. The patients had been prescribed topical IOP-lowering agent and used it for 1 year. The morphologic features of the TM and SC were collected using anterior segment module of spectral-domain optical coherence tomography with enhanced depth imaging at baseline. Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. We investigated the effects of baseline TM and SC microstructures on IOP reduction amount. Results: The baseline IOP of 69 glaucomatous eyes was 17.9 ± 3.8 mmHg, and the mean amount of IOP reduction was 3.5 ± 2.1 mmHg after 1 year. Mean TM widths of nasal and temporal sector were 470.33 ± 80.05 and 479.74 ± 79.59 μm, respectively. SC area was measured as 4,818.50 ± 1,464.28, 4,604.23 ± 1,567.73 μm2 at nasal sector and temporal sector, respectively. The correlation analysis revealed a positive correlation between SC area and average amount of IOP reduction, indicating that the larger baseline SC area, the greater the IOP drop with topical IOP-lowering agents. However, no correlation was found between TM width and IOP lowering amount in patients with POAG. Conclusions: The baseline SC area showed positive correlation with the IOP reduction amount in patients with POAG. This finding suggests that the SC area can be a clinical parameter to predict the IOP reduction amount before using IOP-lowering agents in POAG patient. © Korean Journal of Ophthalmology 2021.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.