Characteristics, management, and clinical outcomes of patients with hospital-acquired and ventilator-associated pneumonia: A multicenter Cohort study in Korea
- Authors
- Ko, R.-E.; Min, K.H.; Hong, S.-B.; Baek, A.-R.; Lee, H.-K.; Cho, W.H.; Kim, C.; Chang, Y.; Lee, S.-S.; Oh, J.Y.; Lee, H.B.; Bae, S.; Moon, J.Y.; Yoo, K.H.; Jeon, K.; the Korean HAP/VAP Study Group
- Issue Date
- 2021
- Publisher
- Korean National Tuberculosis Association
- Keywords
- Epidemiology; Healthcare-Associated Pneumonia; Korea; Mortality; Ventilator-Associated Pneumonia
- Citation
- Tuberculosis and Respiratory Diseases, v.84, no.4, pp.317 - 325
- Indexed
- SCOPUS
KCI
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 84
- Number
- 4
- Start Page
- 317
- End Page
- 325
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/138406
- DOI
- 10.4046/TRD.2021.0018
- ISSN
- 1738-3536
- Abstract
- Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are significant public health issues in the world, but the epidemiological data pertaining to HAP/VAP is limited in Korea. The objective of this study was to investigate the characteristics, management, and clinical outcomes of HAP/VAP in Korea. Methods: This study is a multicenter retrospective cohort study. In total, 206,372 adult patients, who were hospitalized at one of the 13 participating tertiary hospitals in Korea, were screened for eligibility during the six-month study period. Among them, we included patients who were diagnosed with HAP/VAP based on the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) definition for HAP/VAP. Results: Using the IDSA/ATS diagnostic criteria, 526 patients were identified as HAP/VAP patients. Among them, 27.9% were diagnosed at the intensive care unit (ICU). The cohort of patients had a median age of 71.0 (range from 62.0 to 79.0) years. Most of the patients had a high risk of aspiration (63.3%). The pathogen involved was identified in 211 patients (40.1%). Furthermore, multidrug resistant (MDR) pathogens were isolated in 138 patients; the most common MDR pathogen was Acinetobacter baumannii. During hospitalization, 107 patients with HAP (28.2%) had to be admitted to the ICU for additional care. The hospital mortality rate was 28.1% in the cohort of this study. Among the 378 patients who survived, 54.2% were discharged and sent back home, while 45.8% were transferred to other hospitals or facilities. Conclusion: This study found that the prevalence of HAP/VAP in adult hospitalized patients in Korea was 2.54/1,000 patients. In tertiary hospitals in Korea, patients with HAP/VAP were elderly and had a risk of aspiration, so they were often referred to step-down centers. Copyright © 2021 The Korean Academy of Tuberculosis and Respiratory Diseases.
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