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A Case of Early-Onset Alzheimer's Disease Mimicking Schizophrenia in a Patient with Presenilin 1 Mutation (S170P)
- Authors
- Kim, Hang-Rai; Jang, Ja Hyun; Ham, Honggi; Choo, Seung Ho; Park, Jeongho; Kang, Sung Hoon; Hwangbo, Song; Jang, Hyemin; Na, Duk L.; Seo, Sang Won; Baek, Ji Hyun; Kim, Hee Jin
- Issue Date
- 2021
- Publisher
- IOS PRESS
- Keywords
- Alzheimer' s disease; positron emission tomography; PSEN1 mutation; psychosis
- Citation
- JOURNAL OF ALZHEIMERS DISEASE, v.83, no.3, pp.1025 - 1031
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ALZHEIMERS DISEASE
- Volume
- 83
- Number
- 3
- Start Page
- 1025
- End Page
- 1031
- ISSN
- 1387-2877
- Abstract
- Atypical psychological symptoms frequently occur in early-onset Alzheimer's disease (EOAD), which makes it difficult to differentiate it from other psychiatric disorders. We report the case of a 28-year-old woman with EOAD, carrying a presenilin-1 mutation (S170P), who was initially misdiagnosed with schizophrenia because of prominent psychiatric symptoms in the first 1-2 years of the disease. Amyloid-beta positron emission tomography (PET) showed remarkably high tracer uptake in the striatum and thalamus. Tau PET showed widespread cortical uptake and relatively low uptake in the subcortical and medial temporal regions. Our case advocates for considering EOAD diagnosis for young patients with psychiatric and atypical cognitive symptoms.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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