Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Database: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Mok, Lydia | - |
dc.contributor.author | Heo, Jin Seok | - |
dc.contributor.author | Han, In Woong | - |
dc.contributor.author | Shin, Sang Hyun | - |
dc.contributor.author | Yoon, Yoo-Seok | - |
dc.contributor.author | Han, Ho-Seong | - |
dc.contributor.author | Hwang, Dae Wook | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Lee, Woo Jung | - |
dc.contributor.author | Park, Sang Jae | - |
dc.contributor.author | Park, Joon Seong | - |
dc.contributor.author | Kim, Yonghoon | - |
dc.contributor.author | Lee, Huisong | - |
dc.contributor.author | Yu, Young-Dong | - |
dc.contributor.author | Do Yang, Jae | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Park, Il Young | - |
dc.contributor.author | Jeong, Chi-Young | - |
dc.contributor.author | Roh, Younghoon | - |
dc.contributor.author | Kim, Seong-Ryong | - |
dc.contributor.author | Moon, Ju Ik | - |
dc.contributor.author | Lee, Sang Kuon | - |
dc.contributor.author | Kim, Hee Joon | - |
dc.contributor.author | Lee, Seungyeoun | - |
dc.contributor.author | Kim, Hongbeom | - |
dc.contributor.author | Kwon, Wooil | - |
dc.contributor.author | Lim, Chang-Sup | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.contributor.author | Park, Taesung | - |
dc.date.accessioned | 2022-03-12T23:40:50Z | - |
dc.date.available | 2022-03-12T23:40:50Z | - |
dc.date.created | 2021-12-06 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138781 | - |
dc.description.abstract | Background/Aims: Several prediction models for evaluating the prognosis of nonmetastatic resected pancreatic ductal adenocarcinoma (PDAC) have been developed, and their perfor-mances were reported to be superior to that of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. We developed a prediction model to evaluate the prognosis of resected PDAC and externally validated it with data from a nationwide Korean database. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) database were uti-lized for model development, and data from the Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP) database were used for external validation. Potential candidate variables for model de-velopment were age, sex, histologic differentiation, tumor location, adjuvant chemotherapy, and the AJCC 8th staging system T and N stages. For external validation, the concordance index (C-index) and time-dependent area under the receiver operating characteristic curve (AUC) were evaluated. Results: Between 2004 and 2016, data from 9,624 patients were utilized for model develop-ment, and data from 3,282 patients were used for external validation. In the multivariate Cox proportional hazard model, age, sex, tumor location, T and N stages, histologic differentiation, and adjuvant chemotherapy were independent prognostic factors for resected PDAC. After an exhaustive search and 10-fold cross validation, the best model was finally developed, which included all prognostic variables. The C-index, 1-year, 2-year, 3-year, and 5-year time-dependent AUCs were 0.628, 0.650, 0.665, 0.675, and 0.686, respectively. Conclusions: The survival prediction model for resected PDAC could provide quantitative sur-vival probabilities with reliable performance. External validation studies with other nationwide databases are needed to evaluate the performance of this model. (Gut Liver, Published online May 7, 2021) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | CELL LUNG-CANCER | - |
dc.subject | PROGNOSTIC-FACTOR | - |
dc.subject | SURGERY | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | MORTALITY | - |
dc.subject | NOMOGRAM | - |
dc.subject | GRADE | - |
dc.subject | HEAD | - |
dc.title | Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Database: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Young-Dong | - |
dc.identifier.doi | 10.5009/gnl20306 | - |
dc.identifier.scopusid | 2-s2.0-85119267153 | - |
dc.identifier.wosid | 000701865200001 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.15, no.6, pp.912 - 921 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 912 | - |
dc.citation.endPage | 921 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002776226 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTOR | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | NOMOGRAM | - |
dc.subject.keywordPlus | GRADE | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordAuthor | Pancreatic& | - |
dc.subject.keywordAuthor | nbsp | - |
dc.subject.keywordAuthor | neoplasms | - |
dc.subject.keywordAuthor | Survival& | - |
dc.subject.keywordAuthor | nbsp | - |
dc.subject.keywordAuthor | Proognosis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.