Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen's disease)
- Authors
- Baek, Yoo Sang; Jeon, Jiehyun; Kim, Aeree; Song, Hae Jun; Kim, Chungyeul
- Issue Date
- 3월-2020
- Publisher
- JOHN LIBBEY EUROTEXT LTD
- Keywords
- Bowen' s disease; Human papillomavirus; Next-generation sequencing; Squamous cell carcinomain situ; alpha-human papillomavirus
- Citation
- EUROPEAN JOURNAL OF DERMATOLOGY, v.30, no.2, pp.111 - 118
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF DERMATOLOGY
- Volume
- 30
- Number
- 2
- Start Page
- 111
- End Page
- 118
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139088
- DOI
- 10.1684/ejd.2020.3700
- ISSN
- 1167-1122
- Abstract
- Background The detection rate of human papillomavirus (HPV) in Bowen's disease (BD) varies greatly. Objectives To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD. Materials and Methods We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples. Results HPV was detected in 26 (26.3%) BD samples. A total of 10 types of alpha-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%). Conclusion The present study suggests that sexually transmitted mucosal alpha-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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