Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | 오남수 | - |
dc.date.accessioned | 2022-04-08T01:41:13Z | - |
dc.date.available | 2022-04-08T01:41:13Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1949-0976 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139639 | - |
dc.description.abstract | Previously, a synbiotic combination of probiotic Lactobacillus gasseri 505 (LG) and a new prebiotic, Cudrania tricuspidata leaf extract (CT) in fermented milk, designated FCT, showed an in vitro immunomodulatory effect and antioxidant activity. Although synbiotic combination might have cancer-protective effects, these activities have not been fully validated in vivo. Ten-week treatment of LG, CT, or FCT to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated colorectal cancer (CAC) mouse model reduced both the incidence of colonic tumors and damage to the colonic mucosa effectively, suggesting a cancer-protective effect. To understand these, biomarkers associated with inflammation, colon barrier, apoptosis, and cancer cell proliferation were monitored in AOM/DSS group versus LG/CT/FCT groups. A synbiotic combination (FCT) down-regulated pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) and inflammation-associated enzymes (iNOS and COX-2), and up-regulated anti-inflammatory cytokines (IL-4 and IL-10). In addition, colon barrier experiment revealed that biomarkers of mucus layer (MUC-2 and TFF3) and tight junction (occludin and ZO-1) were up-regulated. Subsequent apoptosis experiment showed that pro-apoptotic factors (p53, p21, and Bax) were up-regula | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR AND FRANCIS INC.325 CHESTNUT ST, SUITE 800PHILADELPHIAPA 19106 | - |
dc.title | Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 오남수 | - |
dc.identifier.doi | https://doi.org/10.1080/19490976.2020.1785803© 202 | - |
dc.identifier.bibliographicCitation | GUT MICROBES, pp.1 - 20 | - |
dc.relation.isPartOf | GUT MICROBES | - |
dc.citation.title | GUT MICROBES | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 20 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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