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Memory of Chirality in a Flow-Based System: Enantioselective Synthesis of Quaternary alpha-Amino Acids Using Flow Microreactors
- Authors
- 김희진
- Issue Date
- 12월-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Amino acids; Asymmetric synthesis; Continuous flow; Flash chemistry; Flow chemistry; Memory of chirality
- Citation
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no.47, pp.6754 - 6757
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Number
- 47
- Start Page
- 6754
- End Page
- 6757
- ISSN
- 1434-193X
- Abstract
- Enantioselective synthesis of quaternary alpha-amino acids based on alkylation of a conformationally unstable enolate according to a memory-of-chirality strategy was successfully adapted to a flow-based system. This allows for the scale-up of this enantioselective process with reaction residence times of less than three minutes. The enantiomeric excess values are similar to those obtained in the batch process.
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