Development of Toroidal Nanostructures by Self-Assembly: Rational Designs and Applications
- Authors
- 김용주
- Issue Date
- 12월-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- ACCOUNTS OF CHEMICAL RESEARCH, v.46, no.12, pp.2888 - 2897
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACCOUNTS OF CHEMICAL RESEARCH
- Volume
- 46
- Number
- 12
- Start Page
- 2888
- End Page
- 2897
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139979
- DOI
- 10.1021/ar400027c
- ISSN
- 0001-4842
- Abstract
- Toroidal nanostructures are symmetrical ring-shaped structures with a central internal pore. Interestingly, in nature, many transmembrane proteins such as beta-barrels and alpha-helical bundles have toroidal shapes. Because of this similarity, toroidal nanostructures can provide a template for the development of transmembrane channels. However, because of the lack of guiding principles for the construction of toroids, researchers have not widely studied the self-assembly of toroidal nanostructures as compared with the work on other supramolecular architectures. In this Account, we describe our recent efforts to construct toroidal nanostructures through the self-assembly of rationally designed building blocks. In one strategy for building these structures, we induce interfacial curvatures within the building blocks. When we laterally graft a bulky hydrophilic segment onto a p-oligophenyl rod or beta-sheet peptides, the backbones of the self-assembled structures can bend in response to the steric effect of these large side groups, driving the p-oligophenyl rod or beta-sheet peptides to form nanosized toriods. In another strategy, we can build toroids from bent-shaped building blocks by stacking the macrocycles. Aromatic segments with an internal angle of 120 degrees can associate w
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