SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Soo-Jin | - |
dc.contributor.author | Shin, Ok Sarah | - |
dc.date.accessioned | 2022-04-18T08:42:49Z | - |
dc.date.available | 2022-04-18T08:42:49Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140279 | - |
dc.description.abstract | With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.subject | NUCLEAR IMPORT | - |
dc.subject | PROTEASE | - |
dc.subject | NUP98 | - |
dc.title | SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Ok Sarah | - |
dc.identifier.doi | 10.1007/s12275-022-1525-1 | - |
dc.identifier.scopusid | 2-s2.0-85124254948 | - |
dc.identifier.wosid | 000751590600001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.60, no.3, pp.290 - 299 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 60 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 290 | - |
dc.citation.endPage | 299 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002813848 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | NUCLEAR IMPORT | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | NUP98 | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | interferon | - |
dc.subject.keywordAuthor | immunity | - |
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