Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

Authors
Oh, Soo-JinShin, Ok Sarah
Issue Date
3월-2022
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Keywords
SARS-CoV-2; COVID-19; interferon; immunity
Citation
JOURNAL OF MICROBIOLOGY, v.60, no.3, pp.290 - 299
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MICROBIOLOGY
Volume
60
Number
3
Start Page
290
End Page
299
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/140279
DOI
10.1007/s12275-022-1525-1
ISSN
1225-8873
Abstract
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Shin, Ok Sarah photo

Shin, Ok Sarah
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE