Effect of Calcium Dobesilate in Preventing Contrast-Induced Nephropathy in Patients with Diabetes and Chronic Kidney Disease
DC Field | Value | Language |
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dc.contributor.author | Zhang, Hao | - |
dc.contributor.author | Guo, Shao-Hua | - |
dc.contributor.author | Xue, Zheng-Kai | - |
dc.contributor.author | Zhang, Ya-Ru | - |
dc.contributor.author | Wang, Jia-Rui | - |
dc.contributor.author | Che, Jing-Jin | - |
dc.contributor.author | Liu, Tong | - |
dc.contributor.author | Tao, Hua-Yue | - |
dc.contributor.author | Li, Guang-Ping | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Ashraful-Haque, Swapnil-Zaman | - |
dc.contributor.author | Chen, Kang-Yin | - |
dc.date.accessioned | 2022-05-03T12:42:40Z | - |
dc.date.available | 2022-05-03T12:42:40Z | - |
dc.date.created | 2022-05-03 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1807-5932 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140698 | - |
dc.description.abstract | OBJECTIVES: This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD). METHODS: A total of 130 patients with diabetes and CKD estimated glomerular filtration rate: 30-90 mL/min/1.73m(2) were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure. RESULTS: The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1 +/- 19.6 mmol/L vs. 87.0 +/- 19.3 mmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000). CONCLUSIONS: This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | RENAL-FAILURE | - |
dc.subject | RISK-FACTORS | - |
dc.subject | CYSTATIN C | - |
dc.subject | INJURY | - |
dc.subject | ANGIOGRAPHY | - |
dc.subject | BIOMARKERS | - |
dc.subject | MELLITUS | - |
dc.title | Effect of Calcium Dobesilate in Preventing Contrast-Induced Nephropathy in Patients with Diabetes and Chronic Kidney Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.6061/clinics/2021/e2942 | - |
dc.identifier.scopusid | 2-s2.0-85121051659 | - |
dc.identifier.wosid | 000711216400001 | - |
dc.identifier.bibliographicCitation | CLINICS, v.76 | - |
dc.relation.isPartOf | CLINICS | - |
dc.citation.title | CLINICS | - |
dc.citation.volume | 76 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | RENAL-FAILURE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | CYSTATIN C | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordAuthor | Calcium dobesilate | - |
dc.subject.keywordAuthor | Contrast-Induced Acute Kidney Injury | - |
dc.subject.keywordAuthor | Diabetes Mellitus | - |
dc.subject.keywordAuthor | Chronic Renal Insufficiency | - |
dc.subject.keywordAuthor | Coronary Angiography | - |
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