Effect of Calcium Dobesilate in Preventing Contrast-Induced Nephropathy in Patients with Diabetes and Chronic Kidney Disease
- Authors
- Zhang, Hao; Guo, Shao-Hua; Xue, Zheng-Kai; Zhang, Ya-Ru; Wang, Jia-Rui; Che, Jing-Jin; Liu, Tong; Tao, Hua-Yue; Li, Guang-Ping; Rha, Seung-Woon; Ashraful-Haque, Swapnil-Zaman; Chen, Kang-Yin
- Issue Date
- 2021
- Publisher
- HOSPITAL CLINICAS, UNIV SAO PAULO
- Keywords
- Calcium dobesilate; Contrast-Induced Acute Kidney Injury; Diabetes Mellitus; Chronic Renal Insufficiency; Coronary Angiography
- Citation
- CLINICS, v.76
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICS
- Volume
- 76
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/140698
- DOI
- 10.6061/clinics/2021/e2942
- ISSN
- 1807-5932
- Abstract
- OBJECTIVES: This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD). METHODS: A total of 130 patients with diabetes and CKD estimated glomerular filtration rate: 30-90 mL/min/1.73m(2) were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure. RESULTS: The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1 +/- 19.6 mmol/L vs. 87.0 +/- 19.3 mmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000). CONCLUSIONS: This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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